Toxic effects of calcium carbide forced ripened pawpaw on the kidney of the Wistar rats

There is a global upsurge in terminal diseases due to unnoticed intake of toxic chemicals. One such chemical Calcium carbide, which has been used ripen fruits by vendors. The aim this study showcase the effect carbide coerced ripened Pawpaw on kidney. Mature unripe Pawpaw’s were plucked off from parent plant at Yenagoa, Bayelsa State. dividing into two groups; one group was kept and allowed rip normal room temperature while other induced with Carbide ripe Histology Laboratory, Medical University, 10gram placed bowl containing 5ml water for dissolution closed metal bucket 1kg fruit [pawpaw] rapped black nylon days[48 hours] ripening. After ripening, sampled washed juiced. 600g both naturally calcium pawpaw peeled separately blended an electric blender 350ml/1L deionized water. juice filtered poured clean bottles labeled [CaC2 juice]; then stored refrigerator subsequent use. 21 adult Wister rats sexes weighing between 126.9- 214.3g used. They divided three groups each sex, based body weight different concentrations administered orally. LD50 carried out using Lorke, 1983 [13] method administration samples nine [9] Wistar rats. 12 main experiment. Group 1: Normal control 4 [2 males 2 females] receive feeds only as placebo. : Treatment [1] received 5ml/kg juice. 3: [2] weeks. natural CaC2 against weighed, sacrificed groups, week blood organ collected hematological histopathological analysis. Results showed increase Creatinine, Urea, Albumin treated contrast (p<0.05). Also there moderate severe renal tubular degeneration necrosis control. In conclusion causes complete failure subsequently death may arise.